Natural Products In Drug Discovery And Development Ppt To Pdf


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Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

Copy embed code:. Automatically changes to Flash or non-Flash embed. WordPress Embed Customize Embed. URL: Copy. Presentation Description No description available. Deepak Sarangi M. Defined composition with a pharmacological effect. What is the process of Drug Discovery and Development? Development: Discovery vs. Dimasi , Choose a disease 2. Choose a drug target 3. Identify a bioassay 4. Find a lead compound 5. Isolate and purify the lead compound 6. Determine the structure of the lead compound 10 1.

Choosing a Disease: 1. Understand how the genes are altered and how that affects the proteins they encode. Choosing a Drug Target: 2. Choosing a Drug Target Drug Targets Discovering drug targets Target specificity and selectivity between species Target specificity and selectivity within the body Targeting drugs to specific organs and tissues Pitfalls 12 3.

Identifying a bioassay: 3. Finding a lead compound: 4. Finding a lead compound e Starting from the natural ligand or modulator Natural ligands for receptors — Adrenalin , nor adrenalin Natural substrates for enzymes — enkephalins Enzyme products as lead compounds — Product of an enzyme catalysed reaction — L- benzyl succinic acid Carboxypeptidase catalysed hydrolysis Natural modulators as lead compounds 15 5. Isolation and purification: 5. Isolation and purification If the lead compound is present in a mixture of other compounds it has to be isolated and purified.

Structure determination: 6. It is important to identify the binding roles of different groups. Making drugs less resistant to drug metabolism Introducing metabolically susceptible groups Self destruct drugs 4. Each success is built on many, many prior failures Advances in understanding human biology and disease are opening up exciting new possibilities for breakthrough medicines. These possibilities will grow as our scientific knowledge expands and becomes increasingly complex. Research-based pharmaceutical companies are committed to advancing science and bringing new medicines to patients.

Follow us on:. Go to Application. US Go Premium. PowerPoint Templates. Upload from Desktop Single File Upload. Drug design ppt sarangi. Post to :. URL :. Related Presentations :. Add to Channel. The presentation is successfully added In Your Favorites. Views: Category: Education. Like it 0. Dislike it 0. Added: September 09, Posting comment Premium member. Presentation Transcript. What is a drug? Discovery vs. Development Discovery includes: Concept, mechanism, assay, screening, hit identification, lead demonstration, lead optimization Discovery also includes In Vivo proof of concept in animals and concomitant demonstration of a therapeutic index Development begins when the decision is made to put a molecule into phase I clinical trials 6.

Determine the structure of the lead compound Choosing a Drug Target Drug Targets Discovering drug targets Target specificity and selectivity between species Target specificity and selectivity within the body Targeting drugs to specific organs and tissues Pitfalls Finding a lead compound e Starting from the natural ligand or modulator Natural ligands for receptors — Adrenalin , nor adrenalin Natural substrates for enzymes — enkephalins Enzyme products as lead compounds — Product of an enzyme catalysed reaction — L- benzyl succinic acid Carboxypeptidase catalysed hydrolysis Natural modulators as lead compounds Structure activity relationships: Structure activity relationships The aim here is to discover which parts of the molecule are important to biological activity and which are not.

Identification of a pharmacophore: Identification of a pharmacophore The pharmacophore summarizes the important binding groups which are required for activity and their relative positions in space with respect to each other.

Drug optimization : Strategies in drug design — Contd. Simplification of the structure Rigidification of the structure Conformational blockers Structure based drug design and molecular modelling -X-Ray crystallography Drug design by NMR The elements of luck and inspiration You do not have the permission to view this presentation.

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Drug discovery

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The therapeutic properties of plants have been recognised since time immemorial. Many pathological conditions have been treated using plant-derived medicines. These medicines are used as concoctions or concentrated plant extracts without isolation of active compounds. Modern medicine however, requires the isolation and purification of one or two active compounds. Drug discovery is a multidimensional problem requiring several parameters of both natural and synthetic compounds such as safety, pharmacokinetics and efficacy to be evaluated during drug candidate selection. This has resulted in increased speed in drug discovery and evaluation of the safety, pharmacokinetics and efficacy of candidate compounds whilst allowing novel ways of drug design and synthesis based on natural compounds.


HERBAL MEDICINE Drugs or lead compound can be isolated from natural source. DRUG DEVELOPMENT The process of bringing a new.


Natural Products in Drug Discovery

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Natural products have been an important source of lead compounds for drug discovery. We collected 19, natural products structures, reported biological activities and virtual screening results. Principal component analysis was employed to explore the chemical space, and we found that there was a large portion of overlap between natural products and FDA-approved drugs in the chemical space, which indicated that natural products had large quantity of potential lead compounds.

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Drug discovery

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Drug discovery using natural products is a challenging task for designing new leads. It describe the bioactive compounds derived from natural resources, its phytochemical analysis, characterization and pharmacological investigation. It focuses on the success of these resources in the process of finding and discovering new and effective drug compounds that can be useful for human resources. From many years, natural products have been acting as a source of therapeutic agents and have shown beneficial uses. Only natural product drug discovery plays an important role to develop the scientific evidence of these natural resources. The development of new technologies has revolutionized the screening of natural products in discovering new drugs. Utilizing these technologies gives us an opportunity to perform research in screening new molecules using a software and database to establish natural products as a major source for drug discovery.

Вспомнив всю услышанную от шефа ложь, она похолодела и посмотрела на него, в глазах ее мелькнуло подозрение. - Это вы убили Танкадо. Стратмор вздрогнул и замотал головой: - Конечно. Убивать Танкадо не было необходимости. Честно говоря, я бы предпочел, чтобы он остался жив. Его смерть бросает на Цифровую крепость тень подозрения.

Она бесхитростна и целеустремленна, и когда достигнет своей цели, то скорее всего совершит цифровое самоубийство.  - Джабба театральным жестом указал на громадный экран.  - Дамы и господа, - он опять тяжело вздохнул, - перед вами компьютерный агрессор-камикадзе… червь. - Червь? - с недоумением переспросил Бринкерхофф. Название показалось ему чересчур земным для такого агрессора. - Червь, - недовольно сказал Джабба.

В то прохладное осеннее утро у него был перерыв в занятиях, и после ежедневной утренней пробежки он вернулся в свою трехкомнатную университетскую квартиру. Войдя, Дэвид увидел мигающую лампочку автоответчика.

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In the fields of medicine , biotechnology and pharmacology , drug discovery is the process by which new candidate medications are discovered.

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