Human Mu Opioid Receptor Gene Polymorphisms And Vulnerability To Substance Abuse Pdf


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15.05.2021 at 01:07
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human mu opioid receptor gene polymorphisms and vulnerability to substance abuse pdf

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Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. The relationships among polymorphisms may be important in determining the risk profile for complex diseases such as addiction, but opioid addiction is a multifactorial syndrome which is partially hereditary and partially affected by the environment.

An overview of the genetics of substance use disorders

Article views PDF downloads Cited by 0. Previous Article Next Article. Research article. Download PDF. This case-control study was done on heroin addicts and non-addicts Iranian male. Genomic DNA was extracted from peripheral blood cells using salting out method. Overall, our results did not support an association between OPRM1 variants and risk of heroin dependence in a sample of southeast Iranian population.

Association between single-nucleotide polymorphisms SNPs in mu opioid receptor gene and drug addiction has been shown in various studies. Here, we have evaluated the existence of polymorphisms in exon 3 of this gene in Iranian population and investigated the possible association between these mutations and opioid addiction. Association between genotype and opioid addiction for each mutation was not statistically significant. Among all receptors involved in opioid addiction, mu opioid receptor MOR is the major one mediating opioid tolerance and dependence Bart et al. This receptor is encoded by a gene called OPRM1 which expands more than 80 kbp of nucleotide sequences on chromosome 6q and is composed of transcript regulatory region, introns and exons Pan et al.

Opioid receptors have been targeted for the treatment of pain and related disorders for thousands of years and remain the most widely used analgesics in the clinic. All four receptors are G-protein coupled and activate inhibitory G proteins. These receptors form homo- and heterodimeric complexes and signal to kinase cascades and scaffold a variety of proteins. The authors discuss classic mechanisms and developments in understanding opioid tolerance and opioid receptor signaling and highlight advances in opioid molecular pharmacology, behavioral pharmacology, and human genetics. The authors put into context how opioid receptor signaling leads to the modulation of behavior with the potential for therapeutic intervention.

Mu Opioid Receptor Gene: New Point Mutations in Opioid Addicts

Metrics details. Like other complex diseases including drug addiction, genetic factors can interfere with the disease. We propose that rs of the OPRM1 gene is a genetic risk factor for drug addiction among Jordanian males. Peer Review reports. Drug addictions are chronic complex diseases that featured by repetitive and irresistible consumption of certain drugs that lead to temporary euphoria.

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Previous reports on the functional effects i. Here we examine the effect of this polymorphism on implicit reward learning. We used a probabilistic signal detection task to determine whether this polymorphism impacts response bias to monetary reward in 63 healthy adult subjects: 51 AA homozygotes and 12 G allele carriers. OPRM1 AA homozygotes exhibited typical responding to the rewarded response—that is, their bias to the rewarded stimulus increased over time.

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